Transcriptional analysis of islets of Langerhans from organ donors of different ages

ABSTRACT: Islet function diminishes with age and as such the incidence of type 2 diabetes increases. The cause of this is unknown. In this study whole islets were extracted with laser capture microdissection from organ donors 1-81 years of age. Increasing age was associated with a downregulation of pathways associated with the cell cycle and increase in markers of senescence e.g. CDKN2A. Among novel genes increasing with age was SPP1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165121 | GEO | 2021/02/18

REPOSITORIES: GEO