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Morphogenetic and transcriptomic signature of syncytialization from human trophoblast stem cells

ABSTRACT: We reveal that STB which differentiated from hTSCs could recapitulate morphogenetic events that physiologically occur during human embryo implantation. STB could also recapitulate the genetic signature of trophoblast differentiation during implantation. It will provide a reliable model to investigate the syncytialization of trophoblast during implantation. Our discovery was potentially valuable in advancing not only our current understanding of implant progression but also paying the way to investigate recurrent implantation failure.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165131 | GEO | 2022/05/05

REPOSITORIES: GEO

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Morphogenetic and transcriptomic signature of syncytialization from human trophoblast stem cells

Project description:Morphogenetic and transcriptomic signature of syncytialization from human trophoblast stem cells

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