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Genome-wide localization of Gcn5 under normal and stress conditions in S. cerevisiae and S. pombe

ABSTRACT: Here we studied genome-wide localization of Gcn5 under normal and KCl stress conditions in both yeast species. We found that in Saccharomyces cerevisiae, the enrichment of Gcn5 on genes changes from a relatively even distribution between coding region and intergenic region in the absence of stress, to a predominant localization in gene coding regions under stress conditions. This altered pattern changes are at global level indicates an important role of Gcn5 in modifying chromatin structure for stress adaptation in S. cerevisiae. The altered pattern changes are not observed in Saccharomyces pombe suggesting the different regulatory mechinery between two yeast speices. The related data series is GSE5218, where we have compared the gene regulation of Gcn5 at expression level in S. cerevisiae and S. pombe.

ORGANISM(S): Saccharomyces cerevisiae Schizosaccharomyces pombe Saccharomyces cerevisiae/Schizosaccharomyces pombe fusant

PROVIDER: GSE16514 | GEO | 2010/03/01

SECONDARY ACCESSION(S): PRJNA122913

REPOSITORIES: GEO

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Comparison of gene regulation by Gcn5 under KCl stress in S. cerevisiae and S. pombe

2010-01-01 | GSE5218 | GEO

Comparison of gene regulation by Gcn5 under KCl stress in S. cerevisiae and S. pombe

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Stress-specific role of the fission yeast Gcn5 acetylatransferase in programming a subset of stress-response genes

Project description:We have found Gcn5 is specifically requried for KCl and CaCl2 mediated stress in Schizosaccharomyces Pombe. We have charaterised the genome wide gene expression responses to KCl stress and show the Gcn5 in involved in the regulation of sebset of stress response genes. Keywords: stress response

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Genome-wide localization of Gcn5 under normal and stress conditions in S. cerevisiae and S. pombe

Project description:Genome-wide localization of Gcn5 under normal and stress conditions in S. cerevisiae and S. pombe

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