RNA seq of sorted T cell subsets from PBMCs and rectal biopsies from humans and rhesus macaques

ABSTRACT: Memory CD4 T cells facilitate HIV establishment following transmission and contribute to HIV persistence during suppressive antiretroviral therapy (ART). Numerous studies have highlighted the importance of memory CD4 T cells expressing the surface integrin heterodimer, α4β7 in HIV infection. Here, we focused on delineating the molecular characteristics of α4β7+ CD4 T cells and determining how transcriptional profiles of circulating α4β7hi CD4 T cells corresponded to that within the lower GI tract.

ORGANISM(S): Homo sapiens Macaca mulatta

PROVIDER: GSE165213 | GEO | 2021/01/21

REPOSITORIES: GEO