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Interleukin-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice

ABSTRACT: The gene expression difference between CBA/J and DBA/2 mice after the injection of CAWS (Candida albicans water-soluble fraction) was compared using an oligo-DNA microarray.

ORGANISM(S): Mus musculus

PROVIDER: GSE16529 | GEO | 2009/06/30

SECONDARY ACCESSION(S): PRJNA116095

REPOSITORIES: GEO

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Interleukin-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice

Project description:The gene expression difference between CBA/J and DBA/2 mice after the injection of CAWS (Candida albicans water-soluble fraction) was compared using an oligo-DNA microarray. CAWS was injected into CBA/J and DBA/2 mice. 21 days after the injection, RNA was extracted from the splenocytes and measured using the mouse oligo-DNA 10K micoarray.

2010-06-24 | E-GEOD-16529 | biostudies-arrayexpress

Gene expression in mouse leukocytes after CAWS administration

2013-09-30 | GSE44803 | GEO

Gene expression in mouse leukocytes after CAWS administration

Project description:We performed DNA microarray analyses and compared the difference in the transcriptome between B6 and DBA/2 mice with modest or dramatic sensitivity to CAWS-vasculitis, respectively. Candida albicans water-soluble fraction (CAWS), a mannoprotein-M-NM-2-glucan complex obtained from the culture supernatant of C. albicans NBRC1385, causes CAWS mediated vasculitis (CAWS-vasculitis) with distinct sensitivity among mouse strains. The mouse leukocyte derived from B6 and DBA/2 mice after 2-, 4-, 8-, 9- weeks administration were examined. Each mice was run in singlete or duplicate. Microarray analyses were performed as single-color hybridizations.

2013-09-30 | E-GEOD-44803 | biostudies-arrayexpress

Expression data from mammary gland during pregnancy and lactation of CBA/CaH, QSi5 and Advanced Intercross Line (AIL; CBA/CaH X QSi5, the 14th generation)

Project description:Previously we have shown significant differences in lactation performance, mammary gland histology and expression profiles of mammary transcriptome during peak-lactation (lactation day 9; L9) between the ordinary CBA/CaH (CBA) and the superior QSi5 strains of mice. In the present study, we compared mammary gland histology between CBA and QSi5 at mid-pregnancy (pregnancy day 12; P12). We assessed lactation performance during the first 8 days of lactation of the 13th - 14th generation of the Advanced Intercross Line (AIL) (CBA X QSi5) mice. We utilized an integrative approach to analyzing mammary microarray expression profiles of CBA and QSi5 at P12 and CBA, AIL and QSi5 at L9.

2013-01-22 | GSE32020 | GEO

Gene profiling in CBA and BL/6 bone marrow derived dendritic cells (BMDC)

Project description:Analysis of baseline gene expression in bone marrow derived dendritic cells (BMDC) from female CBA/J (CBA) and C57BL/6 (BL/6) mice. Results provide insight into strain-dependent differences in gene expression.

2014-02-25 | GSE55307 | GEO

Augmented enterocyte damage during Candida albicans and Proteus mirabilis coinfection

Project description:The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally interacts with residing bacteria. We investigated fungal-bacterial interactions by coinfecting enterocytes with the yeast Candida albicans and the Gram-negative bacterium Proteus mirabilis resulting in enhanced host cell damage. This synergistic effect was conserved across different P. mirabilis isolates and occurred also with non-albicans Candida species and C. albicans mutants defective in filamentation or candidalysin production. Using bacterial deletion mutants, we identified the P. mirabilis hemolysin HpmA to be the key effector for host cell destruction. Spatially separated coinfections demonstrated that synergism between Candida and Proteus is induced by contact, but also by soluble factors. Specifically, we identified Candida-mediated glucose consumption and farnesol production as potential triggers for Proteus virulence. In summary, our study demonstrates that coinfection of enterocytes with C. albicans and P. mirabilis can result in increased host cell damage which is mediated by bacterial virulence factors as a result of fungal niche modification via nutrient consumption and production of soluble factors. This supports the notion that certain fungal-bacterial combinations have the potential to result in enhanced virulence in niches such as the gut and might therefore promote translocation and dissemination.

2022-05-09 | PXD031222 | Pride

Expression data from mammary gland during pregnancy and lactation of CBA/CaH, QSi5 and Advanced Intercross Line (AIL; CBA/CaH X QSi5, the 14th generation)

2013-01-22 | E-GEOD-32020 | biostudies-arrayexpress

Expression data in UPEC cystitis in female CBA mice

Project description:Data defines for the first time a whole bladder transcriptome of UPEC cystitis in female CBA mice using genome-wide expression profiling to map early host response pathways stemming from UPEC colonization We used microarrays to detail the global programme of gene expression in UPEC UTI in mice

2011-12-28 | GSE33210 | GEO

Expression data of cartiliage from CBA and STR/ORT mice

Project description:Affymetrix Mouse Gene 1.0 ST Array profiles were generated from acticular cartilage derived from CBA and Str/ort mice at three ages (8W, 18W, 40W), corresponding to stages prior to, at and late after natural osteoarthritis (OA) onset in OA-prone Str/ort mice.

2012-07-31 | GSE33754 | GEO

Gene expression profile of the germaniumu dioxide-related hearing loss cochlea in CBA mice

Project description:Various organ failure induced by chronic intake of GeO2 is one of the well known disease related to mitochondrial dysfunction. The 0.15% GeO2 treated CBA mice shows severe hearing loss in 4M. Here we analyzed cochlear gene expression of 6 months old CBA mice using microarrays treated with normal chow or that containing 0.15% GeO2 for four months. Auditory brainstem response (ABR) analysis confirmed that severe age-related hearing loss occured in GeO2 treated mice, whereas no hearing loss occured in normal chow treated mice. Comprehensive gene expression analysis identified genes correlated with GeO2-induced mithochodrial dysfunction genes and revealed that 28 genes encoding components of the mitochondrial respiratory chain were significantly down-regulated. These observations provide evidence that GeO2-induced hearing loss is associated with the down-regulation of genes involved in the mitochondrial respiratory chain complexes in the cochlea of CBA mice.

2016-07-22 | GSE84735 | GEO

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