Dissecting the stem cell compartment in Csnk1a1 haploinsufficiency

ABSTRACT: We sorted hematopoietic progenitors from mouse bone marrow previously transplanted with either Csnk1a1 fl/+ or Mx1Cre+ bone marrow and performed scRNAseq. We identified cell populations in a continuum of differentiation from quiescent stem cell to cycling lineage-marker expressing progenitor. Our analysis revealed signaling changes in primitive stem cells with Csnk1a1 haploinsufficiency that result in downregulation of inflammatory NFkB signaling while upregulating Myc and E2f dependent pro-proliferative pathways

ORGANISM(S): Mus musculus

PROVIDER: GSE165395 | GEO | 2022/02/27

REPOSITORIES: GEO