High-frequency head impacts cause chronic synaptic adaptations and long-term cognitive impairment [24h post-HFHI]
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ABSTRACT: The goal of this study is to use bulk RNA-sequencing of to observe the effects of High Frequency Head Impacts contibuting to cognitive dysfunction in mice. Our results show HF-HI can alter brain function through synaptic adaptation. HF-HI mice develop chronic cognitive impairments in the absence of traditional brain trauma pathology, and transcriptomic profiling reveals that synapses are a primary target of this effect.
ORGANISM(S): Mus musculus
PROVIDER: GSE165757 | GEO | 2021/01/29
REPOSITORIES: GEO
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