Activation of cGAS-STING signal to inhibit the proliferation of bladder cancer: the immune effect of cisplatin

ABSTRACT: our findings indicated a cisplatin dependent cGAS-STING signal in bladder cancer. This signal could be enhanced by accumulation of dsDNA and chromatin dissociated cGAS and would finally recruit infiltration DCs and CD8+ T cells in bladder cancer bladder cancer tumor microenvironment. However, the specific role and effect of this signal towards bladder cancer tumor microenvironment need to be further clarified.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165767 | GEO | 2021/03/31

REPOSITORIES: GEO