Heterogeneity of hematopoietic progenitors in adult mouse liver

ABSTRACT: To investigate whether liver-resident ILC1s could develop from local hematopoietic progenitors, we analyzed the phenotypic properties of liver CD45+Lin- progenitors. We found that the adult mouse liver contained Lin-Sca-1+Mac-1+ (LSM) hematopoietic progenitors derived from the fetal liver. This population included Lin-CD122+CD49a+ progenitors that could generate liver ILC1s but not conventional NK (cNK) cells. By performing single-cell RNA seq, we show the heterogeneous composition of these hematopoietic progenitors.

ORGANISM(S): Mus musculus

PROVIDER: GSE165785 | GEO | 2021/03/26

REPOSITORIES: GEO