Psuedouridine sequencing rRNA in Rnmt cKO CD4 T cells

ABSTRACT: We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs and small RNAs including snoRNAs. To deterine if had any effect on ribosomal RNA modification we carried out pseudoridine sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE165790 | GEO | 2021/05/13

REPOSITORIES: GEO