Identification and functional analysis of a potential key circRNA in aged mice with perioperative neurocognitive dysfunction

ABSTRACT: Perioperative neurocognitive dysfunction (PND) is emerging as a significant complication of surgery in elderly patients. However, the molecular mechanisms of PND are not well known. Here we applied microarray analysis to identify circular RNAs (circRNAs) in hippocampus from a mouse model of PND and control mice. Then, the dysregulated circRNAs were confirmed via quantitative real-time polymerase chain reaction (qRT-PCR). Then, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to probe the vital functions of dysregulated genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE165798 | GEO | 2021/08/10

REPOSITORIES: GEO