Transcriptomics

Dataset Information

0

Mouse peritoneal macrophages treated with LPS for 6 hours


ABSTRACT: MicroRNA Let-7 has abundant expression in macrophages and can repress the expression of IL-6 via binding the 3'UTR of IL-6 mRNA. Here, the IL-6 ceRNAs, which compete let-7 with IL-6, was investigated by cDNA Microarray. We reveal that RasGRP1 specifically derepress the expression of IL-6 by competing Let-7a in inflammatory response. Our data elucidated a previously uncharacterized coding-independent role of RasGRP1 in innate immunity, providing an insight into the ceRNAs modulation of innate immune response, and found that RasGRP1 have a dual-function in promoting inflammation and inhibiting tumor by a protein-independent or dependent manner respectively, which may well explain why acute inflammation rarely leads to tumorigenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE165800 | GEO | 2021/01/30

REPOSITORIES: GEO

Similar Datasets

2023-10-03 | GSE229204 | GEO
2023-10-03 | GSE228682 | GEO
2011-04-30 | E-GEOD-28959 | biostudies-arrayexpress
2020-05-22 | PXD017434 | Pride
2016-06-30 | E-GEOD-81700 | biostudies-arrayexpress
2013-09-13 | E-GEOD-50806 | biostudies-arrayexpress
2018-03-14 | PXD006081 | Pride
2023-09-06 | GSE218660 | GEO
2011-04-30 | GSE28959 | GEO
2012-12-13 | GSE42877 | GEO