Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Qualitative differences in diseases-associated mutants reveal molecular signatures and aberrant signaling-crosstalk

ABSTRACT: We generated HEK293 cells stably expressing diseases-derived mutants and performed a genome-wide transcriptome analysis using the 60K SurePrint G3 Human gene expression microarray technology. By the analysis of their gene expression profiles, we identified diseases-associated signature genes that may serve as diagnostic markers or therapeutic targets for the diseases.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165823 | GEO | 2022/06/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Qualitative differences in diseases-associated mutants reveal molecular signatures and aberrant signaling-crosstalk

Project description:Qualitative differences in diseases-associated mutants reveal molecular signatures and aberrant signaling-crosstalk

| PRJNA697974 | ENA

gene expression of KYSE510 cells with treatment of 100 nM PAF for 24 hours

Project description:KYSE510 cells were treated with 100 nM PAF for 24 hours,and then KYSE510 cells were collected for gene expression analysis using Agilent SurePrint G3 Human Gene Expression v3 (8×60K) Microarray. Investigation of the gene network of KYSE510 cells regulated by PAF.

2023-12-16 | GSE163355 | GEO

Gene expression of KYSE410 cells with treatment of 10 uM FAK inhibitor (defactinib) for 4 hours and 24 hours

Project description:KYSE410 cells were treated with 10 uM defactinib for 4 hours and 24 hours,and KYSE410 cells were collected for gene expression analysis using Agilent SurePrint G3 Human Gene Expression v3 (8×60K) Microarray. Investigation of the critical gene of KYSE410 cells treated by defactinib.

2022-07-07 | GSE155591 | GEO

SMARCA4 reads PRMT1-mediated H4R3me2a to promote colorectal cancer progression II

Project description:To further investigate the functional associations between PRMT1 and SMARCA4 and explore the biological significance of these interactions, we conducted expression profiling on the Agilent SurePrint G3 Human Gene Expression v3 (8*60K,Design ID:072363) using knockdown of PRMT1 or SMARCA4’s RNA in HCT116 cells.

2020-01-07 | GSE143199 | GEO

SMARCA4 reads PRMT1-mediated H4R3me2a to promote colorectal cancer progression I

2020-01-07 | GSE143198 | GEO

Agilent SurePrint G3 Mouse GE V2.0 Microarray(8*60K,Design ID:074809)

Project description:Agilent SurePrint G3 Mouse GE V2.0 Microarray(8*60K,Design ID:074809)

| PRJNA699158 | ENA

Genome-wide gene expression of NB-1 after treatment of 5-aza-dC, TBT, and combination

Project description:A neuroblastoma cell line, NB-1, was treated with mock, a DNA demethylating agent (5-aza-2'-deoxycytidine: 5-aza-dC), a synthetic retinoic acid (tamibarotene: TBT), and the combination of 5-aza-dC and TBT. A genome-wide gene expression analysis was performed using SurePrint G3 Human Gene Expression 8 x 60K v2 Microarray.

2021-07-23 | GSE180645 | GEO

Genome-wide gene expression of HML58-3 (a derivative cell line of HCT116) after treatment of DAC (decitabine), OR-2003, and OR-2100

Project description:A derivative cell line of HCT116, HML58-3, was established to detect DNA demethylating agents [Okochi-Takada E, Epigenetics. 2018;13:147-55.]. HML58-3 cells were treated with DNA demethylating agents (decitabine, OR-2003, and OR-2100) or mock. A genome-wide gene expression analysis was performed using SurePrint G3 Human Gene Expression 8 x 60K v2 Microarray.

2019-08-01 | GSE134294 | GEO

CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling

Project description:CD109 is a glycosylphosphatidylinositol-anchored glycoprotein highly expressed in several types of human malignant tumors including lung cancers. We investigated the in vivo functions of CD109 protein in malignant lung tumors. CD109+/+ and CD109-/- K-ras[LSL-G12D/+];p53[fl/fl] (KP) mice were sacrificed at 20 to 23 weeks of age and total RNA was extracted from the lung tumors. SurePrint G3 Mouse GE Microarray 8×60K Ver.2.0 were performed.

2020-10-01 | GSE155453 | GEO

Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [III]

Project description:In order to elucidate the role of DNA methylation in the DME gene regulation, global DNA methylation and mRNA expression profiles of human tissues and cell lines were examinde by HumanMethylation450 Bead Chip and SurePrint G3 Human Gene Expression 8×60K v2. We demonstrated DNA methylation landscape of the DME genes in human tissues. Although a fraction of DME genes can be regulated by their DNA methylation, the variable DNA methylation status probably affects drug metabolism and response.

2015-06-16 | GSE67484 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data