Project description:Bats are a widespread group of mammals thought to host a variety of viruses and other disease agents. Here we performed RNA-sequencing on Artibeus jamaicensis infected with the New World arenavirus, Tacaribe Virus, to generate an extensive bat transcriptome.
Project description:Using high throughput sequencing we report chromatin accessibility(ATAC-seq) and transcriptome profiling (RNA-seq)and in mouse brown adipose tissue (BAT) upon cold exposure in wildtype and Dot1L-BAT specific KO mice.
Project description:The interscapular brown adipose tissue (BAT) depots of adult male and female C57BL/6J mice, housed at 22 °C, were analyzed to identify sex differences in the BAT transcriptome at basal housing conditions.
Project description:The primary objective of this prospective observational study is to characterize the gut and oral microbiome as well as the whole blood transcriptome in gastrointestinal cancer patients and correlate these findings with cancer type, treatment efficacy and toxicity. Participants will be recruited from existing clinical sites only, no additional clinical sites are needed.
Project description:Morbillivirus canis (formerly: canine distemper virus, CDV) is a highly contagious pathogen with a broad host range among carnivore species. During respiratory infection, alveolar macrophages (AMs) are among the first cell types facing the virus, which has previously been shown for measles virus infection. While AMs contribute to pulmonary homeostasis, they likewise bear great potential in establishing a pro-inflammatory environment once confronted with viruses. This study aimed to investigate cellular defense responses by AMs, allowing assumptions on early pathogenesis of CDV.
