Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors [ATAC-Seq]

ABSTRACT: We show that loss of Arid1a impairs the differentiation-associated cell cycle arrest of tooth root progenitors through Hh signaling regulation, leading to shortened roots. Our data suggest that Plagl1, as a cofactor, endows Arid1a with its cell type/spatial functional specificity.

ORGANISM(S): Mus musculus

PROVIDER: GSE166354 | GEO | 2021/04/04

REPOSITORIES: GEO