Project description:Hematopoietic stem cells (HSCs) are characterized by their ability to generate all blood cells while retaining their self-renewal capacity. While it is convenient to believe that HSCs represent a homogenous population, several evidences do not support this notion. Here we identified and characterized a HSC population that expressed CD93 on their membrane. This population showed strong molecular dHSC signature, combined with activation features. Thereby, suggesting that they represent an intermediate state between quiescent and active HSCs being more prone to respond upon alterations in the hematopoietic lineage
