Plasma Membrane Integrity Signaling

ABSTRACT: To understand the transcriptional response of mammalian cells to plasma membrane stress we induced partial loss of plasmid membrane integrity by chemogenetic induction of pore forming proteins (Gasderimin and MLKL) or treatment with the detergent digitonin. We monitored transcription with mRNAseq in the immediate hours after plasma membrane damage and identified conserved transcriptional programs.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE166538 | GEO | 2021/10/04

REPOSITORIES: GEO