Lipin2 limits macrophage proinflammatory response.

ABSTRACT: Alterations in Lpin2 encoding the phosphatidate phosphatase Lipin2 cause the autoinflammatory disorder Majeed syndrome. Lipin2 deficiency enhances lipopolysaccharide (LPS)-induced NLRP3 inflammasome formation in macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE166741 | GEO | 2021/02/16

REPOSITORIES: GEO