Gene expression after knockdown of transcription factors in human iPSC-derived cardiac myocytes

ABSTRACT: We report gene expression changes after knockdown of transcription factors in human iPSC-derived cardiac myocytes. In prior experiments we showed that transcription factors known to be important for cardiac development were frequently up-regulated (i.e., "responsive") after small molecule perturbations of cultured iPSC-derived cardiac myocytes. We used RNA sequencing to test whether siRNA-mediated knockdown of transcription factors with different perturbation-responsiveness and tissue-specificity profiles would lead to inappropriate up-regulation of non-myocyte gene sets in cardiac myocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE166823 | GEO | 2021/02/17

REPOSITORIES: GEO