Genomics

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Identification of JMJD1A and JMJD2B target genes in hypoxic colon carcinoma cells


ABSTRACT: The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. This dataset includes expression data obtained from exposing colon carcinoma cells to hypoxia in combination with siRNA-mediated knockdown of the hypoxia-inducible histone demethylases JMJD1A and JMJD2B. Overall design: 18 samples were analyzed. The log2-transformed normalized signal intensities were used for downstream pairwise comparisons (using Partek Genomic Suite): SiControl-Normoxia>SiJMJD1A-Normoxia; SiJMJD1A-Normoxia>SiControl-Normoxia; SiControl-Normoxia>SiJMJD2B-Normoxia; SiJMJD2B-Normoxia>SiControl-Normoxia; SiControl-Hypoxia>SiControl-Normoxia; SiControl-Normoxia>SiControl-Hypoxia; SiControl-Hypoxia>SiJMJD1A-Hypoxia; SiJMJD1A-Hypoxia>SiControl-Hypoxia; SiControl-Hypoxia>SiJMJD2B-Hypoxia; SiJMJD2B-Hypoxia>SiControl-Hypoxia.

INSTRUMENT(S): [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]

ORGANISM(S): Homo sapiens  

SUBMITTER: Lei Qiu  

PROVIDER: GSE166991 | GEO | 2021-11-03

REPOSITORIES: GEO

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