Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NextSeq 500 (Homo sapiens)
ORGANISM(S): Homo Sapiens
SUBMITTER: Stefano Beretta
PROVIDER: GSE167021 | GEO | 2021-12-24
REPOSITORIES: GEO
Action | DRS | |||
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GSE167021_counts.tsv.gz | Tabular |
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Marcovecchio Genni Enza GE Ferrua Francesca F Fontana Elena E Beretta Stefano S Genua Marco M Bortolomai Ileana I Conti Anastasia A Montin Davide D Cascarano Maria Teresa MT Bergante Sonia S D'Oria Veronica V Giamberti Alessandro A Amodio Donato D Cancrini Caterina C Carotti Adriano A Di Micco Raffaella R Merelli Ivan I Bosticardo Marita M Villa Anna A
Frontiers in immunology 20210601
Down syndrome (DS) patients prematurely show clinical manifestations usually associated with aging. Their immune system declines earlier than healthy individuals, leading to increased susceptibility to infections and higher incidence of autoimmune phenomena. Clinical features of accelerated aging indicate that trisomy 21 increases the biological age of tissues. Based on previous studies suggesting immune senescence in DS, we hypothesized that induction of cellular senescence may contribute to ea ...[more]