Genomics

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RNA sequencing of T cells in the genetically encoded mouse model of T cell anergy (W131AOTII)


ABSTRACT: We found that gene signatures characteristic of unresponsive cells were strongly enriched in peripheral W131AOTII CD4 T cells but not in CD4 single positive (CD4SP) thymocytes. Furthermore, loss of Cbl-b in W131AOTII mice significantly altered gene expression profile associated with improved T cell responsiveness.

ORGANISM(S): Mus musculus

PROVIDER: GSE167169 | GEO | 2021/02/22

REPOSITORIES: GEO

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