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Foetal-specific contributors to infant MLL-AF4-driven Acute Lymphoblastic Leukaemia

ABSTRACT: As MLL-rearranged infant leukaemia is known to initiate in utero, we sought to identify developemntal genes expressed in foetal cells that may aid leukaemogenesis. Bulk RNA-Seq was therefore carried out on mouse and human foetal liver blood progenitors (lymphoid-primed multipotent progenitors [LMPPs] and haematopoietic stem cells/ multipotent progenitor cells [HSC/MPPs]) and compared with the same cell types isolated from developmentally later human cord blood and mouse adult bone marrow.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE167234 | GEO | 2021/10/07

REPOSITORIES: GEO

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