Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Acute myeloid leukemia-induced functional inhibition of healthy CD34+ hematopoietic stem and progenitor cells

ABSTRACT: Exposure to AML-derived supernatants significantly inhibited proliferation, cell cycling, colony formation and differentiation of healthy CD34+ HSPC. RNA sequencing of healthy CD34+ HSPC after exposure to leukemic conditions revealed a specific signature of genes related to proliferation, cell cycle regulation and differentiation thereby reflecting their functional inhibition on a molecular level.

ORGANISM(S): Homo sapiens

PROVIDER: GSE167296 | GEO | 2021/02/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq of healthy CD34+ HSPCs after co-culture with myelodyplastic syndrome patient-derived mesenchymal stromal cells

Project description:Cytopenia in at least one of the hematopoietic lineages (RBCs, WBCs or platelets) is a hallmark feature of MDS, indicating the lack of ability to support HSPC proliferation and the retention of their multilineage potential in the bone marrow. Here, wel investigate MDS-MSCs (with and without 5-azacitidine pre-treatment) as feeder layers for healthy CD34+ HSPCs. We performed RNA sequencing of co-cultured CD34+ HSPCs to compare their transcriptomic signatures after exposure to treated vs untreated MDS-MSCs.

2019-09-30 | GSE119916 | GEO

CD34 blood cells

Project description:CD34+ positively isolated from healthy donors (stimulated by G-CSF) with magnetic beads (after blood leukapheresis) CD34- obtained from 10dd cytokine cultured CD34+ Keywords: differentiation

2009-03-01 | GSE11092 | GEO

Changes in CD34 and Erythroid Progenitor Transcriptome After RUNX3 Kock-down

Project description:The associated publication describes a RUNX3-dependent defect in primary human CD34+ HSPC differentiation into the erythroid lineage. This study was designed to determine which genes are potential targets of RUNX3, and could contribute to regulation of erythropoiesis.

2019-03-01 | GSE119264 | GEO

Cd34

Project description:Rattus norvegicus Cd34, CD34 molecule [Source:RGD Symbol;Acc:1306863], is expressed in 6 baseline experiment(s);

| ENSRNOG00000045558 | ExpressionAtlas

cd34

Project description:Xenopus tropicalis cd34, CD34 molecule [Source:NCBI gene;Acc:779603], is differentially expressed in 1 experiment(s);

| ENSXETG00000031415 | ExpressionAtlas

Cd34

Project description:Rattus norvegicus Cd34, CD34 molecule [Source:RGD Symbol;Acc:1306863], is differentially expressed in 25 experiment(s);

| ENSRNOG00000045558 | ExpressionAtlas

CD34

Project description:Sus scrofa CD34, CD34 molecule [Source:VGNC Symbol;Acc:VGNC:86410], is differentially expressed in 3 experiment(s);

| ENSSSCG00000039946 | ExpressionAtlas

CD34

Project description:Sus scrofa CD34, CD34 molecule [Source:VGNC Symbol;Acc:VGNC:86410], is expressed in 4 baseline experiment(s);

| ENSSSCG00000039946 | ExpressionAtlas

CD34

Project description:Homo sapiens CD34, CD34 molecule [Source:HGNC Symbol;Acc:HGNC:1662], is differentially expressed in 122 experiment(s);

| ENSG00000174059 | ExpressionAtlas

Cd34

Project description:Mus musculus Cd34, CD34 antigen [Source:MGI Symbol;Acc:MGI:88329], is differentially expressed in 142 experiment(s);

| ENSMUSG00000016494 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data