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GM-CSF-induced CD40high human blood dendritic cells promote Tfh1 polarization

ABSTRACT: Using single-cell RNA sequencing (10X technology) on CD4+T cells, we report that GM-CSF-activated human blood CD1c+ dendritic cells (DC) (cDC2) drive the differentiation of naïve CD4+ T cells into Tfh1. These Tfh1 cells displayed typical Tfh molecular features, including high levels of PD-1, CXCR5, and ICOS. They co-expressed Bcl6 and T-bet, and secreted large amounts of IL-21 and IFN-γ.

ORGANISM(S): Homo sapiens

PROVIDER: GSE167364 | GEO | 2022/10/01

REPOSITORIES: GEO

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