Transcriptomics,Genomics

Dataset Information

20

Gene expression profiles of LEC, MLC-L, and MSC-BM


ABSTRACT: Gene expression profiles of limbal explant culture-derived epithelial (LEC) and mesenchymal-like cells (MLC-L) and bone marrow-derived mesenchymal stem cells (MSC-BM). To confirm the stem cell signatures of cultured LEC and to establish the source, possible role of the stroma-derived MLC-L . Overall design: Two-condition experiment, LEC vs. MLC-L cells, LEC vs. MSC-BM, MLC-L vs. MSC-BM. Biological replicates: 2 LEC replicates, 2 MLC-L replicates, 2 MSC_BM replicates.

INSTRUMENT(S): Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)

SUBMITTER: geeta Kashyap vemuganti   

PROVIDER: GSE16763 | GEO | 2009-11-01

SECONDARY ACCESSION(S): PRJNA117415

REPOSITORIES: GEO

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Publications

Gene expression profile of epithelial cells and mesenchymal cells derived from limbal explant culture.

Polisetti Naresh N   Agarwal Prasoon P   Khan Imran I   Kondaiah Paturu P   Sangwan Virender S VS   Vemuganti Geeta K GK  

Molecular vision 20100706


PURPOSE: Limbal stem cell deficiency is a challenging clinical problem and the current treatment involves replenishing the depleted limbal stem cell (LSC) pool by either limbal tissue transplantation or use of cultivated limbal epithelial cells (LEC). Our experience of cultivating the LEC on denuded human amniotic membrane using a feeder cell free method, led to identification of mesenchymal cells of limbus (MC-L), which showed phenotypic resemblance to bone marrow derived mesenchymal stem cells  ...[more]

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