Inflammation potentiates JMML-like blood defects in Shp2 mutant Noonan syndrome

ABSTRACT: Hematopoietic stem and progenitor cells derived from a zebrafish model of Noonan syndrome, carrying a patient-associated Shp2-D61G mutation, display an expansion of monocyte/macrophage progenitors with an inflammatory gene expression signature.

ORGANISM(S): Danio rerio

PROVIDER: GSE167787 | GEO | 2021/02/27

REPOSITORIES: GEO