MHC-independent αβ T cells replace epidermal and dermal γδ T cells in Tcrd-/- mice

ABSTRACT: In Tcrd-/- mice, dendritic epidermal T cells (DETC) are known to be replaced by a DETC-population expressing αβ TCR. Here, the TCR-repertoire from Tcrd-/- mouse skin T cells was compared to the one from WT mice. The analysis revealed the existence of T cells expressing MHC-independent αβ TCR and replacing the missing γδ T cells in Tcrd-/- mouse epidermis and dermis.

ORGANISM(S): Mus musculus

PROVIDER: GSE168123 | GEO | 2021/12/21

REPOSITORIES: GEO