Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dissecting OCT4 defines the role of nucleosome binding in pluripotency

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE168142 | GEO | 2021/06/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Dissecting OCT4 defines the role of nucleosome binding in pluripotency.

Project description: Not available

| S-EPMC7611526 | biostudies-literature

Dissecting OCT4 defines the role of nucleosome binding in pluripotency maintenance

Project description:The aim of this study is to dissect the transcription factor OCT4 and reveal which parts of the protein are essential for interaction with nucleosomes and access to closed chromatin. We revealed that the DNA-binding domain mediates the interaction of OCT4 with nucleosomes. Remarkably, nucleosome-binding can be uncoupled from DNA-binding, diminishing the ability of OCT4 to access to closed chromatin, thus losing the pioneer function. We show that the pioneer function of OCT4 is not only essential during reprogramming differentiated cells to pluripotency but also during pluripotency maintenance of embryonic stem cells. Overall, this study shows how pioneer transcription factors interact with nucleosomes to engage the genome and control cellular identity, highlighting that nucleosomes are not always barriers to genome accessibility.

2021-06-24 | GSE168141 | GEO

Dissecting OCT4 defines the role of nucleosome binding in reprogramming

2021-06-24 | GSE167632 | GEO

Dissecting OCT4 defines the role of nucleosome binding in pluripotency

Project description:Dissecting OCT4 defines the role of nucleosome binding in pluripotency

| PRJNA706206 | ENA

Dissecting OCT4 defines the role of nucleosome binding in pluripotency maintenance

Project description:Dissecting OCT4 defines the role of nucleosome binding in pluripotency maintenance

| PRJNA706212 | ENA

Dissecting the role of distinct OCT4-SOX2 heterodimer configurations in pluripotency.

Project description: Not available

| S-EPMC4551974 | biostudies-literature