Epigenetic crosstalk

ABSTRACT: We report a direct interaction between RNA epigenome and DNA epigenome. We demonstrate that m6A methyltransferase METTL3 regulates DNA methylation levels co-transcriptionally. We observed a genome-wide correlation between m6A / METTL3 and occupancy by the DNA demethylase TET1, and m6A reader physically interacts and recruits TET1 to m6A-associated chromatin regions. Our results demonstrates an original but unheeded feed-back regulatory mechanism from RNA epigenome to DNA epigenome and detect a new aspect of epigenetic crosstalk to regulate gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168344 | GEO | 2022/09/09

REPOSITORIES: GEO