Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction

ABSTRACT: To advance our understanding of the dynamics of the gene regulation during each step of in vitro HSPC, we surveyed global gene expression, chromatin accessibility (ATAC-seq), chromatin immunoprecipitation sequencing (ChIP-seq) for active H3K4me3 and repressive H3K27me3 histone mark, from hPSCs and purified intermediates across HSPC differentiation. Methods: ATAC-seq, bulk RNA-seq, scRNA-seq, ChIP-seq, scATAC-seq, Cut & Tag

ORGANISM(S): Homo sapiens

PROVIDER: GSE168372 | GEO | 2022/05/10

REPOSITORIES: GEO