Unravelling the developmental roadmap towards human brown adipose tissue

ABSTRACT: We have developed and characterised functionally and molecularly a new chemically-defined protocol for the differentiation of human pluripotent stem cells (hPSCs) into brown adipocytes (BAs) that overcomes current limitations This protocol recapitulates step-by-step the physiological developmental path of human BAT. The BAs obtained expresses brown adipocyte and thermogenic markers, are insulin sensitive, and responsive to β-adrenergic stimuli. This new protocol is scalable, enabling the study of human BAs at early stages of development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168387 | GEO | 2021/03/07

REPOSITORIES: GEO