Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Endogenous retroviruses reshape early development of human-animal chimeras.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168421 | GEO | 2026/03/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Endogenous retroviruses reshape early development of human-animal chimeras

Project description:The experiments to demonstrate interspecies chimerism open the possibility of a new era of regenerative medicine growing human organs in large animals. However, currently available human pluripotent stem cells (hPSCs) are inefficient at generating human-animal chimeras for reasons unknown, indicating that developmental obstacles need to be overcome. Here, we uncover the diverse roles of primate-specific endogenous retroviruses in early development of human-mouse chimeras. By optimizing culture conditions, we generate a novel hPSC line mimicking human preimplantation epiblast with improved interspecies chimeric competency. This stem cell line is characterized by the hyper-transcription of primate-specific human endogenous retrovirus-H (HERVH). The human-specific protein ESRG, derived from HERVH, represses de novo L1 retrotransposition to safeguard hPSC genome stability that improves the developmental ability and chimeric ratio of preimplantation embryos. However, in contrast, the human-specific endogenous retrovirus-K (HERVK) released from hPSCs affects mouse trophectoderm, and impairs placentation, resulting in compromised implantation of human-mouse chimeras. Antiretroviral treatment on hPSCs for a short time before injection into mouse embryos, rescues the placentation of chimeric embryos with implantation frequency improved. Taken together, our study reveals the important but diverse roles of endogenous retroviruses in interspecies chimerism, and provides a strategy to overcome developmental obstacles in human-animal chimeric embryos.

2026-03-01 | GSE168228 | GEO

Endogenous retroviruses reshape early development of human-animal chimeras [RNA-seq]

Project description:Interspecies chimeras can illuminate the causes of embryonic evolution and open the possibility of a new era of regenerative medicine growing human organs in large animals. Currently, however, available human pluripotent stem cells (hPSCs) are inefficient at generating human-animal chimeras for reasons unknown. Here, we reveal the diverse roles of primate-specific endogenous retroviruses in early development of human-mouse chimeras thereby greatly improving efficiency, leading to the first birth of live chimeras. By optimizing culture conditions, we generate a novel hPSC line mimicking human preimplantation epiblast with improved interspecies chimeric competency. This stem cell line is characterized by the hyper-transcription of primate-specific human endogenous retrovirus-H (HERVH). The human-specific protein ESRG, derived from HERVH, represses de novo LINE-1 retrotransposition so safeguarding hPSC genome stability and improving the developmental ability and chimeric ratio of preimplantation embryos. In addition, the human-specific endogenous retrovirus-K (HERVK(HML2)) released from hPSCs affects mouse trophectoderm, and impairs placentation, resulting in compromised implantation of human-mouse chimeras. Antiretroviral treatment on hPSCs for a short time before injection into mouse embryos, rescues the placentation of chimeric embryos and improves their implantation. Taken together, our study reveals the important but diverse roles of endogenous retroviruses in interspecies chimerism, and provides a strategy to overcome developmental obstacles in human-animal chimeric embryos.

2026-03-01 | GSE168420 | GEO

Endogenous retroviruses reshape early development of human-animal chimeras [ATAC-seq]

2026-03-01 | GSE168419 | GEO

Endogenous retroviruses reshape early development of human-animal chimeras

Project description:Endogenous retroviruses reshape early development of human-animal chimeras

| PRJNA706590 | ENA

Endogenous retroviruses reshape early development of human-animal chimeras.

Project description:Endogenous retroviruses reshape early development of human-animal chimeras.

| PRJNA707337 | ENA

Endogenous retroviruses reshape early development of human-animal chimeras [ATAC-seq]

Project description:Endogenous retroviruses reshape early development of human-animal chimeras [ATAC-seq]

| PRJNA707340 | ENA

Endogenous retroviruses reshape early development of human-animal chimeras [RNA-seq]

Project description:Endogenous retroviruses reshape early development of human-animal chimeras [RNA-seq]

| PRJNA707341 | ENA

Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-01-24 | GSE268270 | GEO

Critical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-04 | E-GEOD-56569 | biostudies-arrayexpress

Repression of endogenous retroviruses is required for mammary gland development and homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-05-18 | GSE149978 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data