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Gene expression analysis in mouse mature T-cells either upon knockdown of L3MBTL3 or rescue with RBPJ WT or F261A/A284V mutant

ABSTRACT: We identified genes upregulated upon depletion of L3MBTL3 in mouse mature T-cells (MT). Additionally, we identified genes downregulated upon rescue with RBPJ WT but not with an L3MBTL3-interacting defecting mutant (F261A/A284V) in MT cells depleted of RBPJ using the CRISPR/Cas9 technology.

ORGANISM(S): Mus musculus

PROVIDER: GSE168506 | GEO | 2022/12/01

REPOSITORIES: GEO

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RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1

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