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Interferon Regulatory Factor 7 (IRF7) in aging of adipose-derived mesenchymal stromal cells

ABSTRACT: We found that Interferon Regulatory Factor 7 (IRF7) is upregulated in adipose-derived stromal cells (MSC) of 12 months-old (middle-age) mice compared with 1 month-old mice. To go in depth into the role of IRF7 in aging of MSC we knocked-down it in 12 months MSC and assessed the transcriptional changes though whole-genome microarray analysis. We investigated the transcriptional changes induced by the Interferon Regulatory Factor 7 (IRF7) knock-down in mesenchymal stromal cells established from the inguinal fat pad of 12-months-old mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE168533 | GEO | 2021/03/10

REPOSITORIES: GEO

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Irf7 orchestrates the immunological reaction in cardiomyocytes upon Adar1 deletion

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