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Transcriptomic analysis in E9.5 heart tubes identify genes dysregulated in Sox7-null heart tubes

ABSTRACT: RNA-seq differential gene expression analysis was accomplished in E9.5 pooled(n = approximately 30) microdissected heart tubes from Sox7-null embryos and a wild-type littermates.

ORGANISM(S): Mus musculus

PROVIDER: GSE168543 | GEO | 2022/03/01

REPOSITORIES: GEO

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Transcriptomic analysis in E9.5 heart tubes identify genes dysregulated in Sox7-null heart tubes

Project description:Transcriptomic analysis in E9.5 heart tubes identify genes dysregulated in Sox7-null heart tubes

| PRJNA708272 | ENA

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Project description:We intended to identify the potential binding targets of SOX7 in mouse during development (E9.5-E10.5)

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Project description:Specification of the mesodermal lineages requires a complex set of morphogenetic events orchestrated by interconnected signaling pathways and gene regulatory networks. The transcription factor Sox7 has critical functions in differentiation of multiple mesodermal lineages, including cardiac, endothelial, and hematopoietic. Using a doxycycline-inducible mouse embryonic stem cell (mESC) line, we have previously shown that expression of Sox7 in cardiovascular progenitor cells promotes expansion of endothelial progenitor cells. Here, we show that the ability of Sox7 to promote endothelial cell fate occurs at the expense of the cardiac lineage. Using ChIP-Seq coupled with ATAC-Seq we identify downstream target genes of Sox7 in cardiovascular progenitor cells and, by integrating these data with transcriptomic analyses, we define Sox7-dependent gene programs specific to cardiac and endothelial progenitor cells. Further, we demonstrate a protein-protein interaction between SOX7 and GATA4 and provide evidence that Sox7 interferes with the transcriptional activity of Gata4 on cardiac genes. In addition, we show Sox7 modulates WNT and BMP signaling during cardiovascular differentiation. Our data represent the first genome-wide analysis of Sox7 function and reveal a critical role for Sox7 in regulating signaling pathways that affect cardiovascular progenitor cell differentiation.

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Gata6 induced XEN-like cells w/o Sox7

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