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The mechano-biological microenvironment of pancreatic ductal adenocarcinoma

ABSTRACT: GelMA hydrogels of different stiffness (5% and 7.5%) provide a microenvironment capable of directing not only pancreatic cancer cell growth but also stiffness- and matrisome-related gene programs. BxPC-3 and PANC-1 cells were chosen for this analysis as representative epithelial and mesenchymal-like cell lines respectively. Transcriptomic signatures of GelMA-embedded cells were compared against those of cells cultured in commonly-used collagen hydrogels (Col).

ORGANISM(S): Homo sapiens

PROVIDER: GSE168574 | GEO | 2025/12/16

REPOSITORIES: GEO

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