Stromal inflammation is a targetable driver of hematopoietic aging [droplet-based scRNAseq]

ABSTRACT: To investigate global changes in the structure of the bone marrow niche with age, we performed droplet-based scRNAseq (10X Genomics) of unfractionated endosteal and central marrow stromal cells (Ter119-/CD45-). 8,735 cells passed QC, and hematopoietic clusters of cells were excluded based on marker gene expression, leaving 2359 cells distributed across 9 distinct clusters for final presentation.

ORGANISM(S): Mus musculus

PROVIDER: GSE168586 | GEO | 2022/11/02

REPOSITORIES: GEO