Gene copy number variation profiling by microarray

ABSTRACT: Here, we investigate focal amplification patterns in and around the BRAF locus in BRAFV600Emutant COLO205 cells that acquire resistance to the MEK inhibitor Sleumetinib / AZD6244 / ARRY-142886. We find that BRAF amplifications occur frequently in COLO205 cells during acquisition of selumetinib resistance and that BRAFamplifications pre-exist selumetinib treatment but occurs predominantly via de novo mutations

ORGANISM(S): Homo sapiens

PROVIDER: GSE168603 | GEO | 2021/03/23

REPOSITORIES: GEO