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Genome-wide methylation profile of uterine cervical carcinoma in Indian patients

ABSTRACT: Cancer of the uterine cervix (CACX) is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. In India, CACX accounts for approximately 1,22,844 new cases and 67,477 deaths annually. Previously, we catalogued global copy-number aberrations [GSE76911] and performed gene expression profiling [GSE122697] in CACX. Interestingly, differential change in the expression between normal and tumor tissues of several genes did not correlate with the chromosomal copy-number alteration. This encouraged us to perform genome-wide DNA methylation analysis. Hence, in the current study, we discover the global methylation in cervical tumors at different clinical stages and HPV-negative normal ectocervix along with HPV16-positive cervical squamous cell carcinoma cell line, SiHa.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168841 | GEO | 2024/03/12

REPOSITORIES: GEO

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Global expression profile of uterine cervical carcinoma in Indian patients.

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