Identification of a novel antitumor CD4+ T cell cluster orchestrating antitumor immunity

ABSTRACT: scRNAseq-based unsupervised clustering and clonotyping revealed that Th1/17 and CCR6 SP clusters formed metacluster Th7R, which was distinct from Th1 or Th17, characterized by high expression of the IL-7 receptor. Use of this cluster to assess antitumor CD4+ T cell immunity from the peripheral blood and to predict the efficacy of immune checkpoint inhibitors will pave the way for novel antitumor immunotherapy strategies for patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168844 | GEO | 2022/12/21

REPOSITORIES: GEO