PTIR1 acts as a suppressor of immunoproteasome and promotes cancer immune resistance

ABSTRACT: Cancer cells evade host immune surveillance by virtue of poor immunogenicity. We identify a novel oncogene that acts as a promotor of tumor immune resistance, designated as PTIR1. Tumor-intrinsic PTIR1 is induced by RNA splicing and highly correlated with poor outcome of patients with cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE168862 | GEO | 2024/02/19

REPOSITORIES: GEO