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Jag1-dependent gene expression in human endometrial stromal cells

ABSTRACT: The goal is to investigate gene regulation in endometrial stromal cells expressing the Notch ligand Jag1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE16906 | GEO | 2009/07/01

SECONDARY ACCESSION(S): PRJNA117689

REPOSITORIES: GEO

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Transcription profiling of human endometrial stromal cells to idenify Jag1-dependent gene expression

Project description:The goal is to investigate gene regulation in endometrial stromal cells expressing the Notch ligand Jag1. Experiment Overall Design: This study compares gene expression in Jag1 retrovirus-infected and control (empty virus-infected) stromal cells.

2009-07-11 | E-GEOD-16906 | biostudies-arrayexpress

RNA sequencing analysis of JAG1 overexpressed Ink4a-/- murine astrocytes

Project description:Notch signaling is a signaling pathway related to development and homeostasis of tissue. Jagged 1 (JAG1), which is one of the ligand of NOTCH, is highly expressed in tumor and induce proliferation, survival and tumor aggressiveness of cancer cells. This study demonstrate the biological function of JAG1 in tumor progression. To elucidate the role of JAG1, JAG1 was overexpressed in murine Ink4a-/- astrocytes. Our results provide the clue of molecular mechanism in tumor aggressiveness.

2025-02-16 | GSE225528 | GEO

JAG1 Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium

Project description:Background: Basal cells (BC) are the stem/progenitor cells of the human airway epithelium capable of differentiating into secretory and ciliated cells. Notch signaling activation increases BC differentiation into secretory cells, but the role of individual Notch ligands in regulating this process is unknown Results: The objective of this study was to define the role of the Notch ligand JAG1 in regulating BC differentiation. JAG1 over-expression in BC increased secretory cell differentiation, with no effect on ciliated cell differentiation. Conversely, knockdown of JAG1 decreased expression of secretory cell genes. Conclusions: These data demonstrate JAG1 mediated Notch signaling regulates differentiation of BC into secretory cells. This study demonstrates that expression of the Notch ligand JAG1 is highly enriched in basal stem/progenitor cells (BC) of the human airway epithelium and that modulation of its expression levels during differentiation of BC play an important role in regulating secretory cell differentiation with no effect on ciliated cell differentiation. These observations have implications for developing novel targets to specifically modulate levels of secretory cells in human airway disorders.

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Jag1

Project description:Rattus norvegicus Jag1, jagged canonical Notch ligand 1 [Source:RGD Symbol;Acc:2937], is expressed in 5 baseline experiment(s);

| ENSRNOG00000007443 | ExpressionAtlas

Jag1

Project description:Rattus norvegicus Jag1, jagged canonical Notch ligand 1 [Source:RGD Symbol;Acc:2937], is differentially expressed in 31 experiment(s);

| ENSRNOG00000007443 | ExpressionAtlas

JAG1

Project description:Sus scrofa JAG1, jagged canonical Notch ligand 1 [Source:VGNC Symbol;Acc:VGNC:96385], is expressed in 2 baseline experiment(s);

| ENSSSCG00000007067 | ExpressionAtlas

JAG1

Project description:Macaca mulatta JAG1, jagged canonical Notch ligand 1 [Source:VGNC Symbol;Acc:VGNC:73808], is differentially expressed in 1 experiment(s);

| ENSMMUG00000018116 | ExpressionAtlas

JAG1

Project description:Macaca mulatta JAG1, jagged canonical Notch ligand 1 [Source:VGNC Symbol;Acc:VGNC:73808], is expressed in 2 baseline experiment(s);

| ENSMMUG00000018116 | ExpressionAtlas

JAG1

Project description:Oryctolagus cuniculus JAG1, jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188], is expressed in 1 baseline experiment(s);

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JAG1

Project description:Equus caballus JAG1, jagged canonical Notch ligand 1 [Source:VGNC Symbol;Acc:VGNC:19209], is expressed in 1 baseline experiment(s);

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