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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2)

ABSTRACT: This study investigates the role of regulatory T cell–derived Areg in driving epithelial repair following influenza infection. We use RNA sequencing to probe the gene expression changes within epithelial cells in wildtype mice and in mice that conditionally lack Areg from T cell sources (CD4-cre Areg-flox). Further, we identify a population of damage-associated transitional alveolar epithelial cells that are induced in reponse to acute injury and exhibit gene expression changes reflective of AT2 transdifferentiation to AT1.

ORGANISM(S): Mus musculus

PROVIDER: GSE169126 | GEO | 2022/12/14

REPOSITORIES: GEO

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2-AEC)

Project description:This study investigates the role of regulatory T cell–derived Areg in driving epithelial repair following influenza infection. We use RNA sequencing to probe the gene expression changes within epithelial cells in wildtype mice and in mice that conditionally lack Areg from T cell sources (CD4-cre Areg-flox). Further, we identify a population of damage-associated intermediate alveolar epithelial cells (AECint) that are induced in reponse to acute injury and exhibit gene expression changes reflective of AT2 transdifferentiation to AT1.

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Integrated transcriptomic and epigenomic analysis of primary human lung cell differentiation (ChIP-Seq)

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Transcriptional profiling of CD44hi AT2 cells under homeostasis and after lung injury [I]

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