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Modulation of PSF binding property at RNA level by small molecule treatment in prostate cancer

ABSTRACT: Prostate cancer is the most common cancer in men and androgen receptor (AR) downstream signalings promote prostate cancer cell proliferation. PSF is a RNA binding protein which is involved in AR signaling.To investigate the effect of samll molecule, No.10-3, on the RNA binding ability of PSF, we performed RNA immunoprecipitation (RIP) sequence analysis in AR positive prostate cancer cell line long term androgen deprivation (LTAD) cells to explore the differences of PSF function to associate with RNAs in prostate cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE169139 | GEO | 2021/05/01

REPOSITORIES: GEO

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