Transcriptomic and epigenetic characterization of PVT neurons in bipolar disorder model mouse.

ABSTRACT: We have previosuly shown that our Polg(D181A) show spontaneous depressive episodes as a result of mtDNA mutations, but we do not know the cellular mechanisms that link mtDNA mutations to behavioural changes. We hypothesized that mtDNA mutation-induced mitochondrial dysfunction in PVT causes a dysregulation of epigenetics, causing a transcriptional response which ffects neuronal function and ultimately causes the depressive phenotype. We assessed this using a combination of RNA-seq, H3K27Ac ChIP-seq, and ATAC-seq and compared our H3K27Ac results to other brain regions.

ORGANISM(S): Mus musculus

PROVIDER: GSE169212 | GEO | 2021/06/01

REPOSITORIES: GEO