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Photosensitivity and c-GAS-dependent type I IFN activation in lupus patients with TREX1 deficiency

ABSTRACT: High throughput screening comparing gene expression in human wildtype and patient (TREX1-mutated) fibroblasts, Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived retinal transcriptome profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods and to evaluate protocols for optimal high-throughput data analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE169244 | GEO | 2021/05/03

REPOSITORIES: GEO

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Photosensitivity and c-GAS-dependent type I IFN activation in lupus patients with TREX1 deficiency

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