PARP-1/PARP-2 double deficiency results in recurrent early pregnancy loss and decidualization failure in mice

ABSTRACT: Specifically, we found inhibition of PARP-1 and PARP-2 catalytic activity, or tissue-specific genetic knockout, results in a severe fertility defect. Transcriptomic analyis uncovered that PARP-1;PARP-2-deficient mice have defects in the progression of stromal cell decidualization manifesting in pregnancy failure

ORGANISM(S): Mus musculus

PROVIDER: GSE169544 | GEO | 2021/09/13

REPOSITORIES: GEO