A Thrombin-PAR1/2 Feedback Loop Amplifies Thrombo-Inflammatory Endothelial Responses To The Viral RNA Analogue Poly(I:C)

ABSTRACT: This study describes a positive feedback mechanism by which thrombin sustains and amplifies the prothrombotic and proinflammatory function of endothelial cells exposed to the viral RNA analogue, poly(I:C) via activation of PAR1/2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171228 | GEO | 2021/04/01

REPOSITORIES: GEO