Low miR-214-5p expression correlates with aggressive subtypes of pediatric ALCL with non-common histology

ABSTRACT: The small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, while miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171323 | GEO | 2021/05/12

REPOSITORIES: GEO